Epidemiology of Typhoid Fever Typhoid fever is a major cause of morbidity and mortality among humans with an estimated global incidence of 21.6 million cases

Salmonella enterica subspecies enterica serotype Typhi (S. Typhi) is the causative agent of typhoid fever that is still a major challenge for public health in developing countries. The bacterium is transmitted by faeco-oral route, through contaminated water or food. Salmonella Typhi is highly adapted to human host; the only reservoir is man. The diagnosis of typhoid becomes difficult as discriminating typhoid from other febrile disease is still unclear.